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10.3892/mmr.2015.4149 56 Lund-JohansenP.OmvikP.NordrehaugJ

The GIP receptor component is believed to enhance metabolic and weight-loss effects, whilst glucagon receptor activation is hypothesised to increase energy expenditure and promote hepatic fat breakdown (lipolysis)

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These results led to the development of lazaroids (21-aminosteroids), in which the steroid skeleton has been improved with addition of an AT component ( in vitro , as well as show neuroprotective activity in various animal models of traumatic brain injury (TBI) and of the spinal cord