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For clinical translation, non-invasive alternatives (e.g., intranasal NSC-derived exosomes, focused ultrasound-enhanced IV delivery) should be prioritized, as pioneered in recent ASD trials using intranasal routes [37, 38]
Fe is first oxidized to Fe, which then binds to transferrin and is endocytosed by cells
A recent metallomic study has found significantly lower cortical lithium (Li) in mild cognitive impairment and AD with selective sequestration of Li within amyloid plaques, implying an early disturbance of endogenous Li homeostasis in vulnerable cortex while serum levels remain unchanged
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