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The 26S mainly degrades polyubiquitinated proteins in an ATP dependent manner and contains caspase-like, trypsin-like and chymotrypsin-like proteolytically active sites in the 1 (PSMB6), 2 (PSMB7), and 5 (PSMB5) subunits of the 20S core 24,41

Site-selected mutagenesis of a conserved nucleotide binding HXGH motif located in the ATP sulfurylase domain of human bifunctional 3-phosphoadenosine 5-phosphosulfate synthase

Presence and Role of Sweet Taste Receptor in Extraoral Tissues Apparently, T1R2/T1R3 is not only responsible for sweet taste detection in the oral cavity, since it is also expressed in several extra oral tissues (Figure 2), together with its downstream signaling molecules (Table 6 and Figure 2) (for review Yamamoto and Ishimaru, 2013

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