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Common side effects observed in Phase 2 trials include nausea, vomiting, diarrhoea, and injection site reactions, particularly during dose escalation

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Elevated arabinose is often associated with yeast (Candida) overgrowth, while abnormal bacterial metabolites may signal an imbalance in the gut microbiota

The second step of the -oxidation is catalyzed by the 2-enoyl-CoA hydratase (ECH), while the third step is catalyzed by 2 distinct forms of the NAD + dependent 3-hydroxyacyl-CoA dehydrogenase that show different specificities: the long-chain hydroxyacyl-CoA dehydrogenase (LCHAD) and the short/medium-chain hydroxyacyl-CoA dehydrogenase (HAD)