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Co-immunoprecipitation studies demonstrated that the peptide reduces eNOS/caveolin-1 binding by approximately 50%, effectively doubling the available eNOS for nitric oxide production

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Shimodaira Y, Slack RS, Harada K, Bhutani MS, Elimova E, Staerkel GA, Sneige N, Erasmus J, Shiozaki H, Charalampakis N, Planjery V, Kaya DM, Amlashi FG, Blum MA, Skinner HD, Minsky BD, Maru DM, Hofstetter WL, Swisher SG , Mares JE, Rogers JE, Lin QD, Ross WA, Weston B, Lee JH, Ajani JA

While some plastics used in syringes are inert, there is a risk of the peptide binding to the plastic over time, which could alter the effective dose