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Covalent warhead was only recognized in the case of acetaldehyde, as expected

Substance Use Disorders (SUD) Substance use interferes with treatment adherence, treatment response, and worsens illness outcomes in BD.[213] Bipolar spectrum disorders are common among SUDs, and often go unrecognized.[214,215] Management for BD and SUD may be initiated simultaneously, especially when withdrawal from substance use is deemed to contribute to mood instability.[216,217] The sparse available literature is summarized here.[213,216,217] For alcohol use disorder comorbid with BD, a randomized trial found that the combination of lithium and divalproex was more effective than lithium alone in reducing drinking frequency

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