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Adverse effects of incretin mimetics Potential adverse effects of incretin mimetics include: Hypoglycemia when taken with insulin GI distress Pancreatitis Renal insufficiency Possible risk of thyroid cancer Other non-insulin, injectable diabetes medications GIP/GLP-1 receptor co-agonists GIP/GLP-1 receptor co-agonists are used to treat type 2 diabetes only

Interestingly, there is cross-talk between sulfonylurea and incretin signaling involving the activation of the exchange protein activated by cyclic-AMP 2A (Epac2A)-Ras-like small GTPase 1 (RAP1) pathway, which may augment insulin secretion from pancreatic -cells upon exposure to the combination of both drugs [45,46]

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