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Ortho -substituted N- phenoxyacetamides delivered the desired para -aminated phenols in good to excellent yields ( 5a5c )

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At the same time, it upregulates the levels of pyruvate kinase (PK), phosphofructokinase-1 (PFK-1), and hepatic glucokinase (GK)enzymes involved in glycolysiswhile inhibiting glucose transporter 2 (GLUT2), promoting the translocation of GLUT4, enhancing glucose uptake by peripheral tissues, accelerating glucose metabolism, and preventing hyperglycemia