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It is a well-established measure to prevent or mitigate the adverse consequences of obesity, offering numerous beneficial effects on whole-body metabolism and inducing favorable adaptations within key metabolic tissues, including muscle, adipose tissue, and liver (1, 49)

May 2022;33(5):270-276

-HB has been shown to exert neuroprotective effects on dopaminergic neurons [52], with consistent evidence from MPTP-induced models of PD, where it prevents the loss of dopaminergic cells in the substantia nigra [53]

Regulatory watch Last reviewed Jul 12, 2026 Next review Jul 24, 2026 Evidence snapshot Human trial record: a Phase 1 safety and pharmacokinetics registry entry has no posted efficacy result