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Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women

Hypertension, for instance, increases cardiac workload and induces left ventricular (LV) hypertrophy, which is compensatory and adaptive in nature and helps to maintain circulatory homeostasis

More recently, it has been suggested that NO from GSNO may be converted to SNO-Hb prior to its release from RBCs (47), perhaps due to the ability of S-nitrosothiols to react with ferrous heme groups in oxyHb