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Sin embargo, tambin es capaz de participar en la conjugacin no enzimtica de algunos productos qumicos, como en el caso de la N-acetil-p-benzoquinona imina (NAPQI), el metabolito reactivo formado por la accin del sistema citocromo P450 sobre el paracetamol (o acetaminofeno, como se conoce en los Estados Unidos)

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As men grow older, testosterone levels decline gradually with free testosterone concentrations falling by about 50% between ages 25 and 75 years