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Importantly, by immunohistochemical (IHC) staining of xenograft tumor tissues, we found that knocking down ACTL6A expression significantly decreased the level of Ki67, a proliferation marker, and increased that of 4-hydroxy-2-noneal (4-HNE) 45 , a lipid peroxidation marker (Fig

equipment was purchased with funds from the University of Wisconsin-Madison, the NIH (P41GM103399, S10RR02781, S10RR08438, S10RR023438, S10RR025062, S10RR029220) and the NSF (DMB-8415048, OIA-9977486, BIR-9214394)

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This historical perspective provides us a list of actions carried out by IGF-I, among others: tissue growth and development, insulin-like activity, proliferative, pro-survival/anti-aging, antioxidant, etc