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Annual OGTT testing is recommended for individuals with prediabetes or established risk factors for PTDM to facilitate early detection and timely intervention ( The International Diabetes Federation estimated that the prevalence of diabetes which was 10.5% in 2021, would increase to 11.3% by 2030 and 12.2% by 2040 ( 3 Pathogenesis of PTDM PTDM is increasingly recognized as a distinct condition from T2DM, despite sharing common pathophysiological pathways ( Figure 1

SIRT1 activation through NAD+ availability triggers multiple metabolic improvements: enhanced insulin sensitivity, increased mitochondrial biogenesis, improved fat oxidation, reduced inflammation, and enhanced stress resistance