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A safe and sustainable rate of weight loss is about 12 pounds per week, and combining diet with exercise can help reduce abdominal fat and improve overall health

doi: 10.3390/ijms241713336, 153 ZhouQ.MengY.LiD.YaoL.LeJ.LiuY.et al

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Furthermore, it has been well described that depression and other psychiatric disorders in which stress plays a key role, show alterations in gut microbiota, what consequently underpins translocation of bacterial products and triggers HPA axis activation [109]