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Early clinical studies can then adopt metabolically defined enrichment strategies and a small set of pre-specified pharmacodynamic endpoints linking target engagement to intratumoral lactate and tissue lactylation, while evaluating mechanism-based combinations, including immunotherapy, within adaptive designs [39]

Senolytic compounds under evaluation in phase 2 clinical trials include a combination of dasatinib (a tyrosine kinase inhibitor approved by FDA for the treatment of leukemia) and quercetin (a flavonoid with anti-inflammatory properties) (Cummings et al., 2024

In addition, we recently reported that exendin-4 increases expression of GLP-1R in a dose-dependent manner in human hepatoma cell lines [19]

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