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The existing literature suggests that while these agents may help optimize metabolic and surgical outcomes, their effects on bone remain highly context-dependent, influenced by factors such as age, baseline bone health, duration of therapy, and degree of weight loss

The illustrative attempts include both highly sophisticated delivery technics (i.e., a suture carrying nanoparticle/pEGFP-basic fibroblast growth factor (bFGF) and pEGFP-vascular endothelial growth factor A (VEGFA) complexes developed to transfer the growth factor genes into injured tendon tissues to promote healing [24], and various growth factors combinations given together [25,26]), and various carriers (i.e., growth factors-loaded collagen sponge

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