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Ten-eleven Translocation (TET) enzymes converts methylcytosine (m 5 C) to hydroxymethylcytosine (hmC), which is not recognized by Dnmt1, it is believed to exclude maintenance methylation allowing for passive demethylation, and it is an intermediate in the active conversion of m 5 C to cytosine (C) 27

At the same time, brain tissue is rich in unsaturated fatty acids and transition metal ions but has relatively fewer antioxidants compared to other organs, creating favorable conditions for oxidative damage

Even when acting to reduce H 2 O 2 , their most important function may be in oxidizing the co-substrate rather than removing ROS (OBrien et al