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In addition, some research found that the development of morphine tolerance in gene mice with -arrestin 2 deletion is delayed [90,94,95], which seems to contradict the aforementioned relationship between internalization and tolerance

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Further, in the FIGHT trial, which was the only trial sufficiently comprehensive to allow for the evaluation of hard outcomes, even though the HR was above 1 for the composite endpoint of hospital admission due to HF, the treatment effect did not reach statistical significance (HR [liraglutide vs