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Under normal physiological conditions, reduced GSH is present in concentrations 10 to 100 times greater than oxidized GSH (GSSG), making the GSH/GSSG ratio a common measure of cellular oxidative stress ( The function of GPX4 is precisely regulated by nuclear factor E2-related factor 2 (NRF2), a key transcription factor that activates the expression of various antioxidant genes, including those encoding GSH synthetase and superoxide dismutase (SOD), facilitating the clearance of excess ROS (Xie et al., 2016

Plasma cysteine, cystine, and glutathione in cirrhosis

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or (3) a composite of cerebrovascular diseases (HR 0.99