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Smaller and earlier trials reported reductions in colonic transit time and improvements in functional gastrointestinal symptoms

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42,43 Overall, these investigational IBTs have all shown statistically significant weight loss compared with placebo, demonstrating how the IBT pipeline continues to evolve and how newer mechanisms may offer even greater weight-loss potential

This indicates an interesting GSH-dependent threshold regulation that is important for the subset-specific functions of B cells and a differential redox-dependent regulation of metabolic activities in these cells