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Primary care relevance: Providers should be aware of the differences in efficacy, cost, and convenience of available therapies SMALL STUDY LOOKS AT HOLDING GLP-1 ANALOGS BEFORE GI PROCEDURES April 2026 Randomized trial finds holding one preprocedure dose of a GLP-1 analog reduces residual gastric volume The issue: GLP-1 analogs are being increasingly prescribed for weight loss and type 2 diabetes, but their gastric-slowing effects have raised concerns about residual gastric volume (RGV) and potential pulmonary aspiration during procedures requiring sedation

It was previously shown that the CBM complex acted as a bridge to transmit the activated TCR signal to the downstream IKK/NF-B and c-Jun N-terminal kinase (JNK) pathways, thereby causing T cell activation (100)

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