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Common signs of insulin resistance include constant hunger, afternoon energy crashes, stubborn weight gain around the midsection, and elevated blood sugar on lab tests

Diagnostic Tests Physical exam: To check an enlarged thyroid, pulse, and other physical signs

In men, estrogens increase serum levels of HDL (high-density lipoprotein) cholesterol, improving cardiovascular condition, and also contribute to the maintenance of bone mass and the maturation of sperm (Pentikinen et al., 2000)

They have emerged as key therapeutic targets in diabetes and obesity research , ranging from GLP-1 analogs like Semaglutide (Ozempic/Wegovy) to dual and triple agonists (Retatrutide) that synergistically enhance glycemic control and promote weight loss