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Contact your GP or diabetes specialist nurse within 2448 hours if: The injection site reaction persists beyond one week or worsens progressively You develop signs of infection at the injection site (increasing pain, warmth, pus, or red streaking) The rash spreads beyond the injection site but without severe symptoms You experience recurrent reactions with each injection The reaction significantly impacts your quality of life or ability to continue treatment If you cannot reach your GP and need urgent advice, contact NHS 111