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The main findings covered in this article include: FDA-approved GLP-1 benchmark with well-characterized GI side effect profile from STEP trials
In the SURMOUNT-1 trial, the highest dose led to about 21% mean body-weight loss, more than older single-receptor peptides
the other acts on motivation
Indeed GLP-1R agonists proved to be efficient for the treatment of type 2 diabetes mellitus 37 and studies indicate they could be used in other indications 26,43,44 such as obesity 45,46 , adverse cardiovascular events 25 , cognitive disorders 44 and non-alcoholic steatohepatitis (NASH) 47
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