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Saponin at 100 g/ml was used as a positive control for 100% cell lysis, blood (1% hematocrit) with DPBS as a negative control for no cell lysis, and DPBS as a blank

Type 3 also involves the LOS not relaxing, but the exaggerated activity of the muscles create chest pain with high amplitude spikes and uncoordinated, premature, vigorous contractions

At 48 weeks, mean percentage changes in body weight from baseline were approximately: In the 12 mg arm, roughly 100% of participants achieved at least 5% body-weight loss, about 83% reached 15% loss, around 63% achieved 20% loss, and approximately 26% crossed the 25% threshold