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In fibromyalgia, oxidative stress has also been linked to pathophysiology (Cordero et al., 2010) with studies suggesting that antioxidant therapies may help reduce elevated pro-oxidative pathways such as lipid peroxidation and mitophagy (Assavarittirong et al., 2017) with melatonin being shown to improve brain function in the GWS model, through modulation of oxidative stress (Madhu et al., 2021)

Serious side effects are rare in small studies, but risks include: Injectionsite infection or allergic reaction

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HRT Black Box Warning Removed: What the FDA's 2025 Decision Means The FDA moved to revise the HRT black box warning in 2025