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63 NEVI OF OTA AND ITO Nevus of Ota (nevus fuscoceruleus ophthalmomaxillaris, oculodermal melanocytosis) presents as speckled grayish-brown to blue-black patches involving the skin, conjunctiva, sclera, tympanic membrane, and/or oral and nasal mucosa in areas innervated by the first and second divisions of the trigeminal nerve

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The significant increase in fissures observed in the PCPA-induced insomnia model group suggests that sleep disturbances may lead to notable changes in brain tissue morphology (Figures 8A,B)