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Supplementary material The Supplementary Material for this article can be found online at: Supplementary Figure 1 GPX1 expression was absent in the cochlear SGNs of gpx1 / mice

For chronic weight management, the FDA-approved indications generally include adults with a BMI of 30 or greater, or BMI 27 or greater with at least one weight-related condition (type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease)

Rather than mimicking GLP1 alone, it is a dual agonist that activates both GLP1 receptors and glucose-dependent insulinotropic polypeptide (GIP) receptors

For example, enzymes called ADP-ribosyltransferases add the ADP-ribose moiety of this molecule to proteins, in a posttranslational modification called ADP-ribosylation