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10.1080/21691401.2018.1543195 Artif

Dihexa is a synthetic hexapeptide that binds to the c-Met receptor (hepatocyte growth factor receptor) and amplifies endogenous HGF signaling, potentiating BDNF-TrkB pathway activity by stabilizing receptor-ligand interactions with binding affinity 10,000,000 times greater than natural ligands

The directional message, that retatrutide is achieving weight loss in the 2530% range, approaching what bariatric surgery delivers, is robust enough that conservative readers should treat it as the current best estimate while staying open to refinement as more data publishes

Sample sizes were small and the study has never been replicated at scale, so take it as suggestive, not definitive