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Gobburu JV, et al

In the process of physiological ageing, both systemic and tissue-specific systems show functional downfalls, which, when projected to the brain, translate into weakening defence and metabolic strain resulting from age-dependent declines of the cardio-vascular system and overall decreases in metabolism

In addition, the activity of PDH is also downregulated by nitro oxide (NO) by directly affecting its PDH-E3 via S-nitrosation, which is independent of HIF-1 (137)

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