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Graphical Abstract Similar content being viewed by others Introduction Depression is a global mental health disorder that significantly impairs the quality of life for millions and imposes a substantial economic burden on society

The launch of generic liraglutide (Teva, August 2025) and anticipated oral GLP-1 options (oral Wegovy approved December 2025, orforglipron pending) offer lower-cost alternatives that may simplify pharmacy benefit management

ViraniSSAlonsoABenjaminEJBittencourtMSCallawayCWCarsonAPet alHeart disease and stroke statistics2020 update: a report from the American Heart Association

These typically subside on their own