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Clinical Insights: Creatine in Calorie Deficits While most creatine research focuses on athletes, several trials demonstrate efficacy in lean mass preservation when calories are restricted: A meta-analysis in Nutr Metab showed that subjects in a 20-30% calorie deficit who took creatine maintained up to 60% more lean mass than non-supplemented controls over 8 weeks

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79 ADSC-EVs have been shown to upregulate type 1 and type 3 collagen via the PI3K/Akt pathway and stimulate angiogenesis, supporting their potential in dermal remodeling