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In 1994, the Journal of the American College of Toxicology (now known as the International Journal of Toxicology) published a conclusion that stated that hydroquinone is a potent cytotoxic agent that causes mutations and alterations to DNA, and that it should not be used in any leave-on type of product

The combined interaction between these two peptides has been documented in several research contexts

Collectively, these studies suggest MPs/NPs potentially exhibiting neurotoxic effects on cerebral tissue and vascular integrity, while negative effects during fetal exposure may be mitigated by placental adaptation