Mitochondrial permeability disrupts the ion gradients across the inner mitochondrial membrane, resulting in mitochondrial depolarization, a loss of oxidative phosphorylation, and an increase in ROS production (Garca-Ruiz et al., 1997)
Fifty-eight patients with ST-segment-elevation MI and thrombolysis were randomized to receive either saline (n = 40) or exenatide (n = 18, 10 g SC and 10 g as an IV bolus 5 min before the onset of reperfusion plus 10 g SC twice daily on the following 2 days) to evaluate whether this GLP-1R agonist could reduce the area of necrosis
445,446 Although the mechanisms related to lipid metabolism in liver regeneration have not been fully elucidated, several potential targets deserve further consideration (Fig
As our findings are based on good-quality studies that were all multinational double-blind randomized placebo-control trials and our meta-analysis was based on a mean follow-up of 3.45 years (minimum 1.5 year maximum 5.4 years), the confounding and attrition bias are controlled, so the risk of unreliable results is diminished
