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The final model was subjected to global refinement and minimization in real space using the module phenix.real_space_refine in PHENIX 55

While the relevance of these findings to human risk remains uncertain due to differences in receptor expression between species, they prompted the inclusion of Boxed Warnings on medication labels

10.1186/1471-2334-8-69 WHO: Global surveillance and control of hepatitis C

Pharmaceutical Packaging Configuration: 600mg/ 10 /box Stability: 36-month shelf life (40/75%RH validated) Storage: Store below 25, protected from light Compliance: 21 CFR Part 211 packaging standards Professional Usage Guide Reconstitution: Dissolve with pH 6.80.2 solvent (30s dissolution) Administration: IM/IV injection per patient condition Regimen: 1 weekly 6 weeks Compatibility: Can be co-administered with 10% vitamin C (98.7% absorption rate) Safety: Phase III: 0.33% AE incidence (n=300) Medical Advisory & Disclaimer Notice: For licensed practitioner use only