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Key limitations of the current research include: Small sample sizes in early or pilot human studies Heavy reliance on animal models that may not reflect real-world substance use Limited duration of studies and inconsistent outcome measures The absence of FDA approval for GLP-1 medications in treating substance use disorders Important context to keep in mind: Addiction is influenced by psychological, social, and environmental factors beyond biology Medications alone are not sufficient to address substance use disorders Evidence-based therapies remain the standard of care At this time, GLP-1 medications should not be considered treatments for opioid, nicotine, or stimulant use disorders

This allows the medication to disperse into the tissue and prevents it from leaking back through the needle track