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Review articles summarizing preclinical BPC-157 literature describe how the peptide has been investigated in models examining angiogenesis-linked bone remodeling and connective tissue regeneration, often in the context of nitric oxideassociated vascular signaling pathways [2]

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The investigators attributed the angiogenic effect to upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) and activation of the Aktendothelial nitric oxide synthase (eNOS) signaling pathway

More severe side effects are rare but can include an allergic reaction or the development of blood clots