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Among the tested strains, Lactobacillus helveticus CCFM1076 showed the strongest therapeutic effect, improving social behavior, restoring 5-HT synthesis and metabolism in both peripheral and central tissues, balancing excitatory-inhibitory neurotransmission, increasing hypothalamic oxytocin, and partially normalizing gut dysbiosis (Kong Q

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Conversely, patients with well-controlled baseline blood pressure, borderline kidney function, or history of hypotensive episodes should discuss semaglutide carefully with their provider