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The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension

O-GlcNAcylation further stabilizes ACSL4, thereby promoting ferroptosis, indicating that hyperglycemia can directly activate this cell death pathway (Qin et al., 2025)

Nevertheless, transcriptional modifications may also lead to delays in recovery, as ongoing perturbations on a transcriptional level were observed for up to 6 months after infection, with PASC patients showing a distinct profile, such as upregulation of the alarmins S100A8 and HMGB1, mediators and markers of innate immune activation (124)

A role for selenium-dependent GPX1 in SARS-CoV-2 virulence