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This trial had several limitations, including a small sample size, confounding effect of pre-FMT antibiotics, control arm being SOC instead of placebo antibiotics or autologous FMT, and short-term follow up (up to 20 days)

Low sodium causes dizziness and nausea, which compounds the retatrutide side effect burden

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This Fc domain serves a dual function: it sterically hinders access to DPP-4, thereby protecting the GLP-1 moiety from enzymatic degradation, and it engages the neonatal Fc receptor (FcRn), facilitating receptor-mediated recycling and preventing lysosomal degradation following cellular uptake