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Thyroid considerations GLP-1 receptor agonists carry a warning about thyroid C-cell tumors based on rodent studies

Off-Label Options Gabapentin Lower NNT of 8 for preventing return to heavy drinking [22] Not FDA-approved for AUD Limited long-term safety data Potentially associated with cases of abuse and overdose [23, 24] Less ideal for ED initiation due to abuse liability GLP-1 Agonists An area of recent interest has been on the potential use of GLP-1 agonists, such as semaglutide and liraglutide , for the treatment of AUD