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It only affects new melanogenesis and not pre-existing pigmentation

Pharmacol Rev (2016) 68(4):9541013

In pooled STEP trial data for semaglutide 2.4 mg: Nausea occurred in ~44% of participants Vomiting in ~24% Symptoms were most common during dose escalation Meals such as burgers, fried foods, and fast-food combinations are more likely to cause these symptoms than smaller, balanced meals

Glossary ART assisted reproductive technology ATP adenosine triphosphate CAT catalase CPM cyclophosphamide Cyt c cytochrome c DOR diminished ovarian reserve FADD fas-associated death domain GCs granulosa cells GPx glutathione peroxidase GPx3 glutathione peroxidase 3 GSH glutathione GSH-Px glutathione peroxidase GSS glutathione synthetase Gsta4 glutathione transferase 4 H2O2 hydrogen peroxide HIF1 hypoxia-inducible factor 1-alpha HO-1 heme oxygenase-1 IFN- interferon gamma IL-18 interleukin 18 IL-1 interleukin 1 beta iNOS inducible nitric oxide synthase IVM in vitro maturation LPS lipopolysaccharides MDA malondialdehyde Mgst1 microsomal glutathione S-transferase 1 MMP mitochondrial membrane potential MPF maturation promoting factor MTX methotrexate MV Mogroside V NAC N-acetylcysteine NF-B nuclear transcription factor B 3-NPA 3-nitropropionic acid Nrf2 nuclear factor erythroid 2-related factor 2 PA Proanthocyanidin PCOS polycystic ovary syndrome PGC1 peroxisome proliferator-activated receptor gamma coactivator 1- POA postovulatory aging POF primary ovarian failure POI primary ovarian insufficiency POLG polymerase subunit gamma Prdx3 peroxiredoxin 3 ROS reactive oxygen species SIRT1 nicotinamide adenosine dinucleotide-dependent deacetylase sirtuin-1 SODs auperoxide dismutases TAS total antioxidant status TFAM transcription factor a tGSH total glutathione TNF tumor necrosis factor-alpha TNFR2 tumor necrosis factor receptor 2 TOS total oxidant status References 1 AbaisJ