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Lian J, Nelson R, Lehner R

J Biol Chem 251 : 42874293 Pisoni RL, Acker TL, Lisowski KM, Lemons RM, Thoene JG 1990 A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis

Cystine starvation has been shown to impede TNBC growth, which affects stem cell properties and chemotherapy resistance in TNBC (27), thereby promoting TNBC cell ferroptosis through activation of the general control nonderepessible 2-eukaryotic translation initiation factor 2 subunit 1-activating transcription factor 4-CHAC1 pathway through the specific cytosolic GSH degradation enzyme CHAC1 (28)

Antibody-dependent cellular phagocytosis In contrast to the role of complement, there is evidence from many viruses for the importance of FcR-mediated effector functions of nAbs in antiviral activity in vivo, particularly from studies comparing nAbs with variants in which FcR binding is eliminated or enhanced 116,117,118