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For injectable GLP-1 medications, magnesium supplements are generally best taken with food to enhance absorption and minimise gastrointestinal discomfort

IV B vitamin delivery ensures that these cofactors are available in abundance for cellular energy pathways

In a study of individuals with ( N = 36) or without ( N = 19) upper gastrointestinal disease (gastritis and/or gastroesophageal reflux disease), no significant difference in exposure to semaglutide was observed between individuals with or without gastrointestinal disease and the agent was well tolerated in these patients [35]

Recently, however, GLP-1 has also been implicated in the induction of autophagy in the liver (He et al., 2016) and in cells (Zummo et al., 2017