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For anyone on these medications, the takeaway is consistent with what physicians have long recommended: a GLP-1 prescription works best as part of a broader, long-term approach to weight management, not a standalone solution

Those with inadequate response despite dose optimization and lifestyle adherence would be stronger candidates for escalation to a more potent agent

Recent date (within 6 months)

They act on GLP-1 receptors in the pancreas (insulin secretion, glucagon suppression), hypothalamus (appetite suppression via POMC/NPY pathways), gastric smooth muscle (delayed emptying), and peripheral tissues including adipose and immune cells