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It can be used in combination with other diabetes medications or as a standalone treatment

B Previous amputation, prior foot ulcer, peripheral neuropathy, foot deformity, peripheral vascular disease, visual impairment, peripheral neuropathy (especially if on dialysis), poor glycemic control, and smoking all represent high risk

However, their high price tags $12,648 per year for tirzepatide and $13,618 per year for semaglutide exceed the typical cost-effectiveness threshold of $100,000 to $150,000 per quality-adjusted life-year (QALY)

A one-month supply of Ozempic (semaglutide) can cost over $1,000 without insurance