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In addition, breast cancer cells that express the EMT transcription factors Twist1, Snail1, and Six1 can enhance the migratory and metastatic potential of neighboring, non EMT tumor cells by activating the GLI-induced transcription factor in a non-cell autonomous manner [81]

doi: 10.1146/ANNUREV-GENET-071819-103836 64 LiuTSongSWangXHaoJ

These signals drive serine phosphorylation of the insulin receptor substrate IRS1, thereby blocking insulin signal transduction and contributing to insulin resistance (McLaughlin et al., 2017)

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