cofactor for glutathione peroxidase The biochemical pathway that makes BH4 requires GTP as the substrate and three dedicated enzymes (GTP cyclohydrolase I, 6‑pyruvoyl‑tetrahydropterin synthase, and sepiapterin reductase); the key redox cofactors used in the pathway and Extracellular Glutathione Peroxidase GPx3 and
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