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Several macrolide antibiotics such as erythromycin and azithromycin have motilin receptor agonistic effects, and have a stimulatory effect on gastric emptying rate (100102)

The combined inflammatory impact of cytotoxicity by CD8+ T cells, immune-mediated perturbations of the islet ECM, and other mechanistic changes lead to cell death and decreased cell mass in a time-dependent manner ( Figure 2 )