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Vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and platelet-derived growth factor (PDGF), along with their receptors, are key proangiogenic factors

Buprenorphine has lower intrinsic efficacy at MORs and thus produces less respiratory depression, making it safer than methadone for management in opioid addicts

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